Open AccessThe use of snake venom derived fibrin glue in hysterorrhaphy of ovine caesarean surgery
Author(s) -
Marcos Chalhoub,
Nereu Carlos Prestes,
Maria Denise Lopes,
Noeme Sousa Rocha,
I. A. Thomazini-Santos,
Maria José Soares MendesGiannini
Publication year - 2000
Publication title -
the journal of venomous animals and toxins/the journal of venomous animals and toxins
Language(s) - English
Resource type - Journals
eISSN - 1678-4936
pISSN - 0104-7930
DOI - 10.1590/s0104-79302000000200007
Subject(s) - fibrin glue , hemostasis , medicine , surgery , wound healing , fibrin , glue , uterus , materials science , immunology , composite material
Fibrin glue has been used on its own or in conjunction with suturing materials to promote hemostasis, reduce adherence, strengthen the wound site, and improve healing. Snake venom derived fibrin glue was evaluated as an alternative to conventional uterine suturing after ovine caesarean surgery. Twenty-eight pregnant ewes of known mating date were used. The animals submitted to conventional caesarean sections showed a better wound healing process. As expected, all the operated animals had retained placenta, compromising coaptation of wound edges. This had a strong influence in the results observed with the animals in which fibrin glue was used. The animals were divided into four groups GI, GII, GIII, and GIV and sacrificed, respectively, 3, 7, 15, and 30 days after surgery for macro and microscopic examination of the uterus. From each group, six animals underwent surgery using fibrin glue and four animals were submitted to comparative conventional hysterorrhaphy using catgut