Open AccessACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL
Author(s) -
Benedito Barraviera,
Bruno Lomonte,
Andrej Tarkowski,
Lars Å. Hanson,
Domingos Alves Meira
Publication year - 1995
Publication title -
the journal of venomous animals and toxins/the journal of venomous animals and toxins
Language(s) - English
Resource type - Journals
eISSN - 1678-4936
pISSN - 0104-7930
DOI - 10.1590/s0104-79301995000100003
Subject(s) - bothrops , crotalus , leukocytosis , neutrophilia , medicine , viperidae , immunology , biology , snake venom , venom , ecology
Thirty-one patients bitten by venomous snakes in Botucatu area (State of SãoPaulo - Brazil), sixteen by Bothrops spp. and fifteen by Crotalus durissus terrificus, werestudied. The group comprised twenty-nine males and two females, ranging from fourteen tosixty-three years of age (mean 33 ± 15). Leukocytosis with neutrophilia and lymphopenia,increase of mucoproteins and C-reactive protein, decrease of total serum protein and albumin,were observed on the first day after the accident. In addition, increased serum levels of thecytokines IL-6 and IL-8, but not of IL-1b and TNF-a, were observed. The alterations weregenerally more intense in patients bitten by Crotalus durissus terrificus than by Bothrops spp.It is concluded that these snakebite envenomations closely resemble an acute trauma,inducing a typical acute-phase response.Ministério da Ciência, Tecnologia, Inovações e Comunicações/[Proc. 300.398/88-3]/CNPq/BrasilFundação para o Desenvolvimento da UNESP/[Proc. 239/91]/FUNDUNESP/BrasilUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP