Open AccessParameters estimation for amino acids adsorption in a fixed bed by moment analysis
Author(s) -
Marco Aurélio Cremasco,
Benjamin Hritzko,
Yi Xie,
N.H. L. Wang
Publication year - 2001
Publication title -
brazilian journal of chemical engineering/brazilian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.313
H-Index - 52
eISSN - 1678-4383
pISSN - 0104-6632
DOI - 10.1590/s0104-66322001000200006
Subject(s) - dispersion (optics) , adsorption , diffusion , chemistry , mass transfer , moment (physics) , phenylalanine , pulse (music) , analytical chemistry (journal) , breakthrough curve , thermodynamics , chromatography , amino acid , physics , classical mechanics , biochemistry , detector , optics
Equilibrium constant and mass transfer parameters are needed for the study of amino acid separation in any process involving adsorption in fixed beds. The adsorption constants, effective diffusion coefficients, and axial dispersion coefficients for two amino acids, L-phenylalanine (Phe) and L-tyrosine (Tyr), are determined from a series of pulse tests in a fixed bed packed with PVP (poly-4-vinylpyridine) resin. Total bed voidage at different flow rates is estimated from NaCl pulse test data. The effective pore diffusivities of Phe, Tyr, and NaCl are estimated from moment analysis of pulse data. A detailed rate model is then solved numerically and adsorption constants, effective diffusion coefficients, axial dispersion coefficients are determined by moment analysis and compared with the pulse data. The advantage of this method is that the effective intraparticle diffusivities can be determined without the influence of extracolumn dispersion or intracolumn axial dispersion effects