Open AccessSIMULATION INVESTIGATIONS TOWARDS THE DEVELOPMENT OF A BACTERIAL BIOPESTICIDE FED-BATCH REACTOR
Author(s) -
César Cunha,
Ana Maria Souto Maior,
Moura Júnior
Publication year - 1998
Publication title -
brazilian journal of chemical engineering/brazilian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.313
H-Index - 52
eISSN - 1678-4383
pISSN - 0104-6632
DOI - 10.1590/s0104-66321998000100004
Subject(s) - bacillus thuringiensis , control theory (sociology) , controller (irrigation) , batch processing , continuous stirred tank reactor , batch reactor , biological system , mathematics , process engineering , engineering , chemistry , computer science , chemical engineering , control (management) , bacteria , biology , genetics , artificial intelligence , agronomy , programming language , biochemistry , catalysis
In this work, the growth of Bacillus thuringiensis var. israelensis, a bioinsecticide producer, is investigated. Experiments were carried out in batch mode in order to obtain kinetic model parameters that were further applied to simulate fed-batch processes. The fed-batch mode allows more flexibility in the control of the substrate concentration in the culture medium. Different techniques, such as constant feeding, "bang-bang" control and model based control (exponential feeding and singular control), were compared. For the techniques based on a model, combinations of models with and without a substrate inhibition parameter were used to represent the simulated process and the internal model of the feeding controller. Singular control based on the model with an inhibition parameter proved to be the most robust controller