Open AccessDYNAMIC MODELLING AND ADVANCED PREDICTIVE CONTROL OF A CONTINUOUS PROCESS OF ENZYME PURIFICATION
Author(s) -
Eduardo César Dechechi,
Marcia Martins,
Rubens Maciel Filho,
Francisco Maugeri
Publication year - 1997
Publication title -
brazilian journal of chemical engineering/brazilian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.313
H-Index - 52
eISSN - 1678-4383
pISSN - 0104-6632
DOI - 10.1590/s0104-66321997000400018
Subject(s) - model predictive control , process (computing) , control theory (sociology) , process control , multivariable calculus , constant (computer programming) , controller (irrigation) , process engineering , matrix (chemical analysis) , computer science , control engineering , engineering , chemistry , control (management) , chromatography , agronomy , artificial intelligence , biology , programming language , operating system
A dynamic mathematical model, simulation and computer control of a Continuous Affinity Recycle Extraction (CARE) process, a protein purification technique based on protein adsorption on solid-phase adsorbents is described in this work. This process, consisting of three reactors, is a multivariable process with considerable time delay in the on-line analyses of the controlled variable. An advanced predictive control configuration, specifically the Dynamic Matrix Control (DMC), was applied. The DMC algorithm was applied in process schemes where the aim was to maintain constant the enzyme concentration in the outlet of the third reactor. The performance of the DMC controller was analyzed in the feed-flow disturbances and the results are presented