Open AccessSpectrophotometric determination of cefaclor in pharmaceutical preparations
Author(s) -
Viviane M. Ivama,
Letícia Norma Carpentieri Rodrigues,
Cláudia C. I. Guaratini,
María Valnice Boldrin Zai
Publication year - 1999
Publication title -
química nova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 73
eISSN - 1678-7064
pISSN - 0100-4042
DOI - 10.1590/s0100-40421999000200011
Subject(s) - cefaclor , yield (engineering) , chemistry , chromatography , hydrolysis , derivative (finance) , dosage form , buffer solution , pharmaceutical formulation , alkaline hydrolysis , materials science , cephalosporin , organic chemistry , biochemistry , antibiotics , metallurgy , economics , financial economics
A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations