Open AccessPerinatal exposure to a high-fat diet alters proopiomelanocortin, neuropeptide Y and dopaminergic receptors gene expression and the food preference in offspring adult rats
Author(s) -
L. S. Santos,
Rhowena Jane Barbosa de Matos,
G. S. Cordeiro,
G. S. Perez,
D. A. E. Santo,
R. T. Silva,
Mariane dos Santos Gonçalves,
Gilson Teles Boaventura,
T. C. B. J. Deiró,
Jairza María Barreto-Medeiros
Publication year - 2022
Publication title -
brazilian journal of biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.472
H-Index - 53
eISSN - 1678-4375
pISSN - 1519-6984
DOI - 10.1590/1519-6984.234855
Subject(s) - offspring , weaning , endocrinology , medicine , biology , lactation , proopiomelanocortin , neuropeptide y receptor , dopaminergic , receptor , pregnancy , neuropeptide , dopamine , hypothalamus , genetics
Exposure to the hight-fat diet may alter the control of food intake promoting hyperphagia and obesity. The objective of this study was to investigate the effects of this diet on dopamine receptors (drd1 and drd2), proopiomelanocortin (pomc), neuropeptideY (npy) genes expression, and preference food in adult rats. Wistar female rats were fed a hight-fat or control diet during pregnancy and lactation. The offspring were allocated into groups: Lactation – Control (C) and High-fat (H). Post-weaning – Control Control (CC), offspring of mothers C, fed a control diet after weaning; Control Hight-fat (CH), offspring of mothers C, fed a hight-fat diet after weaning; Hight-fat Control (HC), offspring of mothers H, fed with control diet after weaning; and Hight-fat Hight-fat (HH), offspring of mothers H, fed a H diet after weaning. The groups CH and HH presented greater expression of drd1 in comparison to the CC. The drd2 of CH and HC presented higher gene expression than did CC. HH presented higher pomc expression in comparison to the other groups. HC also presented greater expression in comparison to CH. The npy of HH presented greater expression in relation to CH and HC. HH and HC have had a higher preference for a high-fat diet at 102º life’s day. The high-fat diet altered the gene expression of the drd1, drd2, pomc and npy, and influencing the food preference for high-fat diet.