Variability and adaptive norm in the system "man-technology-environment, MTE"

Distinguish between hereditary (mutational and combinative) and non-hereditary (modification or phenotypic) variability in the human body. Modificational variability arises as a result of interaction with the surrounding environment, the effects of factors which different people react differently. There is the concept of "reaction norm" as the limit of modification variability, within the capabilities of a particular person. In most cases, modification is a useful adaptive response of the organism, is adaptive in nature (adaptive norm). Adaptive nature is usually inherent in modifications that are caused by the impact of typical factors of a particular environment. If the organism falls under the influence of an unusual factor (for example, exposure to chemicals and radiation), or the intensity of the usual factor is sharply increased, then non-adaptive modifications (morphoses) often manifest themselves as deformities. The wider the norm of the reaction, the higher the human adaptation potential. Unlike mutations, modifications have a different degree of resistance. Many modifications disappear soon after the factor that caused them ceases to function. Others can persist in a person throughout his life. The article considers the possibility of using the achievements of molecular and physico-chemical biology in a comprehensive study of the problem of the normal functioning of the human body in conditions of heightened activity in construction. The authors believe that it is extremely necessary to study the patterns of changes in the state of the adaptive norm of the human body at the level of the genetic apparatus, using the latest developments in nanotechnology. The possibility of enzymatic regulation of alternative ways of regulation by transhypophyseal mechanisms is considered. The concept of the norm of a living system as a hierarchy of structure and functional control is proposed. This hierarchical principle unites the levels of atomic and molecular interactions, realized at negligible distances, to the level of interactions in human society that take place at very great distances, and thanks to which society is an organized system.