Open AccessBiochemical and morphometric methods for assessing cognitive impairment in patients with type 2 diabetes
Author(s) -
Ю. Г. Самойлова,
О. П. Лейман,
О. С. Тонких,
М.В. Матвеева,
Д. А. Кудлай,
O.A. Oleynik,
Н. Г. Жукова,
K.R. Ratkina,
Н. Ю. Фимушкина
Publication year - 2020
Publication title -
kardiovaskulârnaâ terapiâ i profilaktika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.158
H-Index - 16
eISSN - 2619-0125
pISSN - 1728-8800
DOI - 10.15829/1728-8800-2020-2636
Subject(s) - putamen , globus pallidus , medicine , nucleus accumbens , caudate nucleus , white matter , type 2 diabetes , montreal cognitive assessment , magnetic resonance imaging , basal ganglia , hyperintensity , endocrinology , diabetes mellitus , cardiology , cognitive impairment , central nervous system , disease , radiology
Aim . To study the features of biochemical and morphometric parameters in patients with type 2 diabetes (T2D) and cognitive impairment (CI). M aterial and methods. The experimental group included 72 patients with CI and T2D, the control group − 20 patients with T2D and without CI. We used the Montreal Cognitive Scale (MoCA) to assess the presence of CI. We also evaluated the levels of 1,5-anhydroglucitol (1,5-AG), continuous glucose monitoring (CGM), and data of brain magnetic resonance imaging (MRI). R e sults . We revealed that patients with T2D and CI have high HbA1c levels, but there was no significant difference of 1,5-AG levels between the groups. In patients with CI, we also established a decrease in gray and white matter surface area, as well as subcortical structures (the hippocampus, nucleus accumbens and putamen on both sides; the amygdala and globus pallidus on the right). The severity of CI correlated with polyneuropathy severity. In patients with proliferative retinopathy, there was a decrease in the volume of the caudate nucleus, globus pallidus, putamen and nucleus accumbens. Conclusion . The study revealed that patients with T2D with CI have worse levels of carbohydrate metabolism parameters, as well as a decrease in the cortical and subcortical brain structures.