Open AccessGENETIC FACTORS INFLUENCING THE EFFECTIVENESS AND SAFETY OF LONG-TERM ANTICOAGULANT THERAPY
Author(s) -
T Burkova,
И. А. Гончарова
Publication year - 2013
Publication title -
kardiovaskulârnaâ terapiâ i profilaktika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.158
H-Index - 16
eISSN - 2619-0125
pISSN - 1728-8800
DOI - 10.15829/1728-8800-2013-3-89-94
Subject(s) - vkorc1 , warfarin , vitamin k antagonist , medicine , cyp2c9 , anticoagulant therapy , anticoagulant , intensive care medicine , bioinformatics , pharmacology , atrial fibrillation , biology , metabolism , cytochrome p450
Late postoperative thrombotic and haemorrhagic complications in anticoagulant-treated patients remain one of the key problems of the modern clinical medicine. At present, the most widely used anticoagulant is warfarin, a vitamin K antagonist. One of the reasons for a pathological reaction to the therapeutic concentration of warfarin could be individual features of warfarin metabolism, determined by relevant genes. The literature data suggest that protein-coding CYP2C9 and VKORC1 genes play an important role in the development of postoperative complications. However, the individual warfarin dosage can be influenced by a wide range of other genetic polymorphisms.