Open AccessHEART AND AGE (PART I): AGEING THEORIES AND MORPHOLOGICAL CHANGES
Author(s) -
Д. У. Акашева,
И. Д. Стражеско,
Е. Н. Дудинская,
Е В Найденко,
О. Н. Ткачева
Publication year - 2013
Publication title -
kardiovaskulârnaâ terapiâ i profilaktika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.158
H-Index - 16
eISSN - 2619-0125
pISSN - 1728-8800
DOI - 10.15829/1728-8800-2013-1-88-94
Subject(s) - ageing , telomere , oxidative stress , somatic cell , phenotype , biological age , medicine , biology , microbiology and biotechnology , gerontology , genetics , gene
Heart ageing is a complex process including multiple cellular and molecular-level changes and resulting in different ageing phenotypes within the same biological species. According to the existing ageing theories, the multiple interacting mechanisms of ageing include somatic mutations, telomere shortening, oxidative stress, and mitochondrial defects. The review presents the most accepted ageing theories and discusses morphological characteristics of heart ageing on subcellular, cellular, and organ levels.