Open AccessRole of epicardial adipose tissue in the development of cardiovascular diseases
Author(s) -
Irina Mustafina,
В. А. Ионин,
A. A. Dolganov,
В. Ш. Ишметов,
А. Э. Пушкарева,
Timur Yagudin,
К. В. Данилко,
Naufal Zagidullin
Publication year - 2022
Publication title -
rossijskij kardiologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 14
eISSN - 2618-7620
pISSN - 1560-4071
DOI - 10.15829/1560-4071-2022-4872
Subject(s) - medicine , adipokine , adipose tissue , heart failure , epicardial adipose tissue , atrial fibrillation , epicardial fat , biomarker , cardiology , cardiac function curve , endocrinology , obesity , insulin resistance , biochemistry , chemistry
Epicardial adipose tissue (EAT) has unique properties due to its special anatomical structure, thermoregulation, and metabolic activity. Dysregulated EAT provokes the synthesis of pro-inflammatory cytokines, disorders in the metabolism of fats and glucose, as well as contributes to fatty degeneration of the myocardium and heart failure development. EAT may serve as a risk factor and biomarker for cardiovascular diseases, and is also a potential therapeutic target. The purpose of this review was to highlight current research data on EAT, secreted adipokines, their effect on target tissue metabolism, and to systematize the relationship between EAT and cardiovascular diseases. In particular, its function, role in heart failure, atrial fibrillation, as well as the prognostic value of various microRNAs determined in EAT are highlighted.