Open AccessHeart stem cells: hope or myth?
Author(s) -
Pavel Dokshin,
Anna Malashicheva
Publication year - 2021
Publication title -
rossijskij kardiologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 14
eISSN - 2618-7620
pISSN - 1560-4071
DOI - 10.15829/1560-4071-2021-4749
Subject(s) - medicine , regenerative medicine , mesenchymal stem cell , paracrine signalling , induced pluripotent stem cell , stem cell , regeneration (biology) , myocardial infarction , clinical trial , human heart , bioinformatics , neuroscience , cardiology , microbiology and biotechnology , pathology , embryonic stem cell , biology , receptor , biochemistry , gene
The search and study of endogenous heart repair remains an urgent issue in modern regenerative medicine. It is generally accepted that the human heart has a limited regenerative potential, but recent studies show that functionally significant regeneration is possible. However, the mechanisms underlying these processes remain poorly understood. In the heart, there are populations of resident mesenchymal cells that have some properties of stem cells that carry certain markers, such as c-kit + , Sca-1, etc. The ability of these cells to differentiate directly into cardiomyocytes remains controversial, but their use in clinical trials has shown improved cardiac function in patients with myocardial infarction. Currently, approaches are being developed to use, mainly, induced pluripotent stem cells as a promising regenerative therapy, but the cardioprotective role of cardiac mesenchymal cells remains the subject of active study due to their paracrine signaling.