Open AccessPerivascular adipose tissue in the pathogenesis of cardiovascular disease
Author(s) -
O. T. Kim,
В.А. Дадаева,
А. И. Королев,
О. М. Драпкина
Publication year - 2021
Publication title -
rossijskij kardiologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 14
eISSN - 2618-7620
pISSN - 1560-4071
DOI - 10.15829/1560-4071-2021-4567
Subject(s) - medicine , pathogenesis , adipose tissue , adipokine , inflammation , disease , regulator , vasodilation , homeostasis , endocrinology , pathology , bioinformatics , obesity , leptin , biochemistry , chemistry , biology , gene
Perivascular adipose tissue (PVAT) is an active regulator of vascular homeostasis. In physiological conditions, it maintains normal function of vessels, releasing antiatherogenic, anti-inflammatory and vasodilating biologically active substances. Dysfunctional PVAT secretes pro-inflammatory cytokines and adipokines, which play an important role in the development of cardiovascular diseases. This review considers the PVAT function in health and disease, its contribution to the pathogenesis of atherosclerosis, hypertension, aortic aneurysm and vasculitis. In addition, novel methods of non-invasive PVAT assessment and potential strategies for targeted treatment of cardiovascular diseases are presented.