Open AccessRole of renal denervation in the treatment of arterial hypertension: a review
Author(s) -
A. Yu. Orekhov,
Л. К. Каражанова
Publication year - 2021
Publication title -
rossijskij kardiologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 14
eISSN - 2618-7620
pISSN - 1560-4071
DOI - 10.15829/1560-4071-2021-4497
Subject(s) - medicine , denervation , resistant hypertension , cochrane library , medical therapy , adverse effect , renal artery , intervention (counseling) , cardiology , intensive care medicine , blood pressure , meta analysis , randomized controlled trial , kidney , nursing
Regardless of the fact that arterial hypertension is the focus of modern cardiology, resistance to therapy is still an important public health problem with adverse medical, social, and economic consequences. Aim of study: systematizing the available results of studies of the effectiveness of renal denervation in the treatment of patients with resistant AH. Search within databases (PubMed, Cochrane Library) was performed for randomized controlled studies of second-generation catheterassisted renal denervation and sham-controlled studies. We have used PRISMA protocol for preparing our paper. The neutral results of the SYMPLICITY HTN-3 study significantly weakened the interest of practical cardiology in this procedure, however recently published data from the EnligHTNed IDE, SPYRAL HTN OFF MED, and SPYRAL HTN-ON MED studies confirmed the effectiveness and safety of the technique. As the result the second-generation catheters (multielectrode catheters) used for renal denervation confirmed the effectiveness and safety of the procedure, and also expanded the technique usage beyond resistant hypertension. However, the question of the reliability of long-term effects of the procedure still remains, as well as establishing mechanisms to identify predictors of planned intervention responsiveness.