Open AccessImpact of obesity on echocardiographic parameters and N-terminal pro-brain natriuretic peptide levels in patients with heart failure with mid-range ejection fraction: unanswered questions
Author(s) -
Е. А. Лясникова,
А. А. Куулар,
А. В. Павловская,
А. Н. Власенко,
А. В. Козленок,
А. Ю. Бабенко,
М. Ю. Ситникова,
Е. В. Шляхто
Publication year - 2021
Publication title -
rossijskij kardiologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 14
eISSN - 2618-7620
pISSN - 1560-4071
DOI - 10.15829/1560-4071-2021-4462
Subject(s) - medicine , ejection fraction , cardiology , heart failure , natriuretic peptide , body mass index , sinus rhythm , overweight , body surface area , obesity , left ventricular hypertrophy , myocardial infarction , diabetes mellitus , brain natriuretic peptide , endocrinology , blood pressure , atrial fibrillation
Aim . To analyze and compare the clinical, echocardiographic characteristics and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels depending on the central cardiometabolic risk factors, with a focus on obesity, in patients with heart failure (HF) with mid-range ejection fraction (HFmrEF). Material and methods . The study included 111 patients with old myocardial infarction and HFmrEF (men, 100%; mean age, 60 years) predominantly of NYHA class II. Echocardiography and blood sampling for NT-proBNP were performed with sinus rhythm. Left atrial volume (LAV) and left ventricular mass (LVM) were indexed to body surface area (BSA) and height raised to a power. Results . Type 2 diabetes, overweight and obesity were diagnosed in 25%, 19%, 38% of cases, respectively, and were associated with greater changes in the morphologic and functional left ventricular parameters. There were no intergroup differences among patients with and without obesity in the LAV and LVM indexed to BSA. However, in patients with a body mass index (BMI) ≥30 kg/m 2 , the LAV indexed to height squared and LVM indexed to height 2,7 were higher (p 40%. This requires the search for optimal standardization and the development of a unified methodological approach.