Open AccessHormonal determinants of prehypertension in a random sample of St. Petersburg residents: data from the ESSE-RF study
Author(s) -
A. Erina,
М. А. Бояринова,
Е. В. Могучая,
Е. П. Колесова,
Е. Ю. Васильева,
А. С. Алиева,
Н. А. Паскарь,
O. Rotar,
Е. И. Баранова,
Alexandra Konradi,
Е. В. Шляхто
Publication year - 2021
Publication title -
rossijskij kardiologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 14
eISSN - 2618-7620
pISSN - 1560-4071
DOI - 10.15829/1560-4071-2021-4381
Subject(s) - medicine , blood pressure , insulin , insulin resistance , population , homeostatic model assessment , anthropometry , prehypertension , endocrinology , hyperinsulinemia , leptin , obesity , environmental health
Aim . To determine the association of prehypertension (PHTN) with cardiometabolic and hormonal factors in a population sample of St. Petersburg residents. Material and methods . As part of the ESSE-RF epidemiological study, a random sample of 1600 residents of St. Petersburg at the age of 25-64 was examined. All participants signed informed consent and completed the questionnaires. Anthropometry, fasting venous blood sampling, blood pressure (BP) measurements were performed. BP was measured by the OMRON BP monitor (Japan) twice on the right hand in a sitting position. Mean BP was calculated. Respondents, depending on the BP level and availability of antihypertensive therapy, were divided into 3 groups: optimal BP ( 173,0 pmol/L (2,99 [1,22; 7,36], p=0,017), HOMA-IR >2,9 (2,12 [1,42; 3,19], p 173,0 pmol/L (2,14 [1,30; 3,54], p=0,003), HOMA-IR >2,9 (1,83 [1,39; 2,42 ], p536 nmol/L (1,59 [1,25; 2,05], p125 pg/ml (2,05 [1,32; 3,20], p=0,002). Conclusion . In a random sample of St. Petersburg residents, the presence of hyperinsulinemia increases the risk of PHTN and insulin resistance by 3 and 2 times, respectively.