Open AccessAntihypertensive therapy: controlling the processes of replicative cell senescence
Author(s) -
Е. Н. Дудинская,
Л. В. Мачехина,
К. А. Ерусланова,
O. A. Dogotar,
Л. П. Рыльцева,
Н. Ю. Лызлова,
Н. А. Щепин,
Ю. В. Котовская,
О. Н. Ткачева
Publication year - 2020
Publication title -
rossijskij kardiologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 14
eISSN - 2618-7620
pISSN - 1560-4071
DOI - 10.15829/1560-4071-2020-3974
Subject(s) - medicine , telomere , telomerase , oxidative stress , senescence , ageing , insulin resistance , inflammation , angiotensin converting enzyme , diabetes mellitus , cellular senescence , bioinformatics , pharmacology , endocrinology , blood pressure , genetics , dna , biology , phenotype , gene
The review includes data over the past 20 years on the mechanisms of the influence of hypertension and related interdependent conditions, such as insulin resistance, chronic inflammation and oxidative stress on the vascular ageing. The review also discusses modern concepts of the interaction of biological and vascular aging, as well as possible ways of their reversal. The central indicators of biological aging in this review are telomere length and telomerase activity. The article discusses antihypertensive therapy as a possible way to slow down both vascular and biological aging, and describes the results of modern studies on the effect of various antihypertensives, including angiotensin-converting enzyme inhibitors, sartans and others, on the telomeres.