Open AccessLevels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction
Author(s) -
A. Gimadeeva,
A. S. Galyavich,
З. М. Галеева,
Л. В. Балеева
Publication year - 2020
Publication title -
rossijskij kardiologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 14
eISSN - 2618-7620
pISSN - 1560-4071
DOI - 10.15829/1560-4071-2020-2-3724
Subject(s) - kexin , medicine , pcsk9 , subtilisin , body mass index , myocardial infarction , proprotein convertase , cholesterol , endocrinology , lipoprotein , gastroenterology , ldl receptor , enzyme , biochemistry , biology
Aim. To study the levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with acute myocardial infarction (MI). Material and methods. The study included 74 patients with acute MI. PCSK9 was determined by enzyme-linked immunosorbent assay. Results. The mean PCSK9 levels were 479,7±15,4 ng/ml. No significant correlation was found between PCSK9 and total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides. In the group of smokers, a significant inverse correlation was found between the levels of PCSK9 and HDL-C (-0,45; p=0,039). In the group of patients with body mass index <25 kg/m2, a significant inverse correlation of PCSK9 levels with total cholesterol (-0,45, p=0,008), HDL-C (-0,42; p=0,029) and LDL-C (-0,47; p=0,003) was found. Conclusion. In patients with MI, a correlation of PCSK9 levels with lipid profile was found in smokers, as well as in patients with a low body mass index.