Open AccessProgrammed cell death and liver diseases
Author(s) -
Н. А. Онищенко,
З. З. Гоникова,
A. O. Nikolskaya,
Л. А. Кирсанова,
V. I. Sevastianov
Publication year - 2022
Publication title -
vestnik transplantologii i iskusstvennyh organov
Language(s) - English
Resource type - Journals
eISSN - 2412-6160
pISSN - 1995-1191
DOI - 10.15825/1995-1191-2022-1-72-88
Subject(s) - necroptosis , pyroptosis , autophagy , programmed cell death , necrosis , apoptosis , biology , effector , inflammation , pathogenesis , liver cell , medicine , pathology , cancer research , microbiology and biotechnology , immunology , biochemistry
Cell death represents the most critical pathologic entity in liver disease, which dictates pathologic consequences such as inflammation, fibrosis, and cell transformation. We analyzed the conclusions of studies on the involvement of different types of programmed cell death (PCD) in the pathogenesis of liver diseases. Three main forms of PCD (autophagy, apoptosis, necrosis) and five additional, still insufficiently studied PCD – necroptosis, ferroptosis, pyroptosis, partanatosis and entosis – observed in the liver in various acute and chronic diseases are considered. The involvement of several PCD at once in the development of any one pathology and one type of PCD in different pathologies was established. This indicates the existence of cross-regulation of metabolism in the liver cells with different levels of damage in the formation of the main dominant type of PCD. Available results indicate the possibility of attenuation (correction) of functional and morphological manifestations of PCD in the organ by controlled blocking of effector-mediated PCD pathways, as well as targeted induction of autophagy, anti-apoptotic and anti-necrotic mechanisms in liver cells.