Open AccessImmunosenescence as a reason of individualizing immunosuppressive therapy in kidney transplantation
Author(s) -
Veronika Fedulkina,
Andrey Vatazin,
А. В. Кильдюшевский,
А. Б. Зулькарнаев,
D.V. Gubina,
М. П. Федулкина
Publication year - 2021
Publication title -
vestnik transplantologii i iskusstvennyh organov
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 5
eISSN - 2412-6160
pISSN - 1995-1191
DOI - 10.15825/1995-1191-2021-3-171-179
Subject(s) - immunosenescence , medicine , transplantation , kidney transplantation , immunosuppression , immunology , intensive care medicine , kidney transplant , acquired immune system , immunity , immune system
Transplantation in elderly patients is obviously more challenging due to existing underlying diseases, changes in pharmacokinetics of immunosuppressive drugs, polypragmasy, and transformation of immunoreactivity (immunosenescence). Our review presents data on modification of adaptive and innate immunity during aging. It also considers the possibility of both reduced and adapted immunosuppressive therapy in elderly renal transplant recipients in achieving an optimal balance between efficacy and complications.