Open AccessSertoli cells: immunomodulatory properties, methods of isolation and culture
Author(s) -
N. N. Skaletskiy,
G. N. Skaletskaya
Publication year - 2021
Publication title -
vestnik transplantologii i iskusstvennyh organov
Language(s) - English
Resource type - Journals
eISSN - 2412-6160
pISSN - 1995-1191
DOI - 10.15825/1995-1191-2021-3-142-147
Subject(s) - sertoli cell , immune privilege , immune system , isolation (microbiology) , biology , privilege (computing) , transplantation , immunology , medicine , bioinformatics , political science , endocrinology , spermatogenesis , law
Due to complications caused by the inevitable use of immunosuppressive drugs in organ and cell transplantation, the use of natural mechanisms of immunological tolerance identified in animal and human organisms arouses interest. It has long been known that there are certain areas in them, including the testis, where immune reactions are virtually impossible. Our review focuses on the role of Sertoli cells that provide testicular immune privilege. Methods of isolation and cultivation of Sertoli cells are described and their potentials in biology and medicine are discussed.