Open AccessLiver steatosis in brain death donors
Author(s) -
Д. В. Воронов,
М. Г. Минина,
А. К. Чомаев,
И. М. Ильинский,
О. М. Цирульникова
Publication year - 2021
Publication title -
vestnik transplantologii i iskusstvennyh organov
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 5
eISSN - 2412-6160
pISSN - 1995-1191
DOI - 10.15825/1995-1191-2021-1-8-14
Subject(s) - steatosis , contraindication , medicine , liver transplantation , h&e stain , transplantation , fatty liver , pathology , autopsy , organ donation , cause of death , staining , gastroenterology , alternative medicine , disease
Aim . To study the frequency of fatty hepatosis in liver biopsies of consecutive brain death donors before cold preservation. Materials and methods . Liver biopsies (before cold preservation) of 300 consecutive donors with brain death were studied. Histological preparations were stained with hematoxylin and eosin, and tricolor Masson staining was performed. Results . The frequency of different degrees of fat hepatosis in men and women did not differ significantly (>0.05). Fat dystrophy of hepatocytes was absent in more than half of the cases (n = 182; 60.7%). A slight degree of fatty degeneration was diagnosed in 57 (19,0%) donors. In total, 239 (79.7%) donor livers were absolutely suitable for transplantation. Moderate degree of steatosis, which is associated with early biliary complications, was detected in 18 (6.0%) cases, and severe degree, which is a contraindication to the use of the organ for transplantation, was detected in 43 (14.3%) cases. Conclusion . Before cold preservation, liver from brain death donors is relatively rarely unsuitable for transplantation.