Open AccessEvaluation of calcification resistance of xenopericardium treated with polyhydroxy compounds
Author(s) -
М. А. Резвова,
Е. А. Овчаренко,
Т. В. Глушкова,
Yu. А. Kudryavtseva,
Л. С. Барбараш
Publication year - 2021
Publication title -
vestnik transplantologii i iskusstvennyh organov
Language(s) - English
Resource type - Journals
eISSN - 2412-6160
pISSN - 1995-1191
DOI - 10.15825/1995-1191-2021-1-75-83
Subject(s) - glutaraldehyde , polyvinyl alcohol , biomaterial , calcification , tannic acid , calcium , ethylene glycol , ultimate tensile strength , nuclear chemistry , chemistry , materials science , biomedical engineering , organic chemistry , composite material , medicine
Calcification of biomaterials used in prosthetic heart valves has been a challenging issue in cardiovascular surgery. The objective of this work is to compare the efficiency of polyvinyl alcohol (PVA) and tannic acid (TA) modification of xenomaterials, pre-stabilized with glutaraldehyde (GA) and ethylene glycol diglycidyl ether (EGDE), in reducing calcification. Analysis of mechanical properties evaluated under uniaxial tension, showed a significant increase in the tensile strength of the test samples compared to the control (unmodified) samples (p < 0.05). Additional treatment of GA-fixed tissue with PVA and TA significantly reduced the amount of calcium in the samples implanted into rats for a 60-day follow-up (p < 0.05). The level of calcification of samples prestabilized with EGDE and treated with PVA and TA did not differ from the control group (p = 0.063). Cumulative analysis of the study results demonstrated that the GA-fixed biomaterial modified with PVA and TA can reduce calcium-binding activity and increase strength. This indicates the prospects for clinical application of the proposed treatment methods. This being said, the issue of long-term body response requires further study of the long-term stability of the modified biomaterial under physiologic blood flow conditions.