Open AccessIn situ crosslinkable hydrogels for engineered cellular microenvironments
Author(s) -
Кун Мин Парк,
Ки Донг Парк,
V. I. Sevastianov,
Е. А. Немец,
В. Н. Василец
Publication year - 2017
Publication title -
vestnik transplantologii i iskusstvennyh organov
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 5
eISSN - 2412-6160
pISSN - 1995-1191
DOI - 10.15825/1995-1191-2017-3-53-64
Subject(s) - self healing hydrogels , biocompatibility , extracellular matrix , materials science , regenerative medicine , nanotechnology , tissue engineering , in situ , biomedical engineering , chemistry , biochemistry , engineering , polymer chemistry , cell , organic chemistry , metallurgy
In situ crosslinkable hydrogels have been widely used as therapeutic implants and vehicles for a broad range of biomedical applications including tissue regenerative medicine because of their biocompatibility and easiness of encapsulation of cells or signaling molecules during hydrogel formation. Recently, these hydrogel materials have been widely utilized as an artificial extracellular matrix (aECM) because of its structural similarity with the native extracellular matrix (ECM) of the human body and its multi-tunable properties. Various synthetic, natural, and semisynthetic hydrogels have been developed as engineered cellular microenvironments by using various crosslinking strategies. In this review, we discuss how in situ forming hydrogels are being created with tunable physical, chemical, and biological properties. In particular, we focus on emerging techniques to apply advanced hydrogel materials for engineered cellular microenvironments.