Open AccessBIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS
Author(s) -
О. Б. Огарков,
А. Е. Суздальницкий,
П. А. Хромова,
Т. А. Цыренова,
Н. А. Сокольникова,
С. Н. Жданова,
М. Е. Кощеев
Publication year - 2018
Publication title -
infekciâ i immunitet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 5
eISSN - 2313-7398
pISSN - 2220-7619
DOI - 10.15789/2220-7619-2018-4-435-440
Subject(s) - biofilm , microbiology and biotechnology , mycobacterium tuberculosis , genotype , tuberculosis , multiple drug resistance , antibiotics , liquid medium , biology , in vitro , chemistry , bacteria , gene , medicine , genetics , chromatography , pathology
. The data proving low probability of observing Biofilm Formation (BF) by contemporary clinical strains of M. tuberculosis growing on liquid medium in vitro are discussed. A hypothesis about the role of MDR/XDR development hindering BF production was proposed. It was found that strains capable of producing BF grow on Lewenstein–Jensen medium generated R-form specific colonies shaped as a disk with a convex center, “UFO-colonies”. Sixty seven “UFO”- strains were investigated to BF production, resistance to antibiotics and their belonging to the main epidemics clusters of the Beijing genotype (CC1 and CC2-W148). It was shown that MDR/XDR strains were also capable of BF production that, however, was remarkably more frequent in strains of CC1 and CC2-W148 genotypes. Thus, it was hypothesized that BF production might potentially influence an outcome of chronic forms of TB-infection.