Open AccessSUSCEPTIBILITY TO ANTIBIOTICS IN KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY MEDICAL CENTRE
Author(s) -
Н. С. Козлова,
Н. Е. Баранцевич,
Е. П. Баранцевич
Publication year - 2018
Publication title -
infekciâ i immunitet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 5
eISSN - 2313-7398
pISSN - 2220-7619
DOI - 10.15789/2220-7619-2018-1-79-84
Subject(s) - ertapenem , fosfomycin , klebsiella pneumoniae , microbiology and biotechnology , meropenem , imipenem , piperacillin , ticarcillin , tazobactam , clavulanic acid , antibiotics , ampicillin , tigecycline , antibiotic resistance , amikacin , biology , medicine , amoxicillin , pseudomonas aeruginosa , escherichia coli , bacteria , biochemistry , genetics , gene
Susceptibility to 16 antimicrobial agents in 421 Klebsiella pneumoniae strains, isolated in a multidisciplinary medical centre from patients with nosocomial infections in 2015, was tested. The majority of studied strains were resistant to antibiotics: ampicillin/clavulanic acid (91.4%), ticarcillin/clavlanic acid (81.9%), piperacillin/tazobactam (69.4%), fluorochinolones (83.6%), III and IV generation of cephalosporines (79.8%), gentamycin (72.9%); one third (34.2%) demonstrated resistance to amikacin. K. pneumoniae strains demonstrated high level of carbapenem resistance (53.0% — to ertapenem, 42.8% — to meropenem and 37.1% — to imipenem), associated resistance to at least 3 different classes of antibiotics — caphalosporins, aminoglycozides, fluorochinolones, that amounted to more than half of the strains (57.7%), including 44.2% of the strains, additionally resistant to carbapenems. The lowest level of resistance was found to fosfomycin (8.5%) and tigecycline (7.4%), resistant cultures showed intermediate resistance with MIC 2 μg/ml to the latter. High diversity of antimicrobial resistance spectra was found, with high level of multidrug resistant strains (87.2%). Resistance to carapenems in K. pneumoniae isolated in the multidisciplinary medical center was determined by either blaOXA-48 (59.3% of isolates, resistant to carbapenems) or blaNDM-1 (40.7%).