Open AccessTHE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS
Author(s) -
Н. И. Ковалевич,
N. S. Sarkisyan,
Е. Л. Ракитина,
В. А. Галяс,
И. В. Санникова,
О В Махиня
Publication year - 2017
Publication title -
infekciâ i immunitet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 5
eISSN - 2313-7398
pISSN - 2220-7619
DOI - 10.15789/2220-7619-2016-4-384-388
Subject(s) - brucellosis , neopterin , medicine , proinflammatory cytokine , acute phase protein , immunology , lipopolysaccharide , cytokine , lipopolysaccharide binding protein , inflammation , immune system
The purpose of the study was to determine the level of proinflammatory cytokines: IL-12, IL-8 and IFN, neopterin and lipopolysaccharide-binding protein in the serum of patients with acute brucellosis before and after antibiotic therapy. The clinical data from 32 patients with laboratory-confirmed diagnosis acute brucellosis admitted to the diagnosis, treatment and examination of occupational diseases brucellosis GBUZ SC City Clinical Hospital No. 2, the city of Stavropol were used in the study. The concentrations IL-12, IL-8, IFN cytokines and acute-phase proteins in serum was determined by ELISA. In the acute phase of brucellosis infection (before treatment) had high levels of pro-inflammatory cytokines IL-8 and IFN, but despite holding a course of antibiotic treatment in the serum of patients with preserved high levels of IL-8, indicative of active inflammation in the absence of clinical manifestations. IL-12 level, a key cytokine in the initiation of lymphocyte-dependent immune response was lower than in the control group. Evaluation of the cytokine status (IL-8, IL-12, IL-18) and proteins of acute inflammation phase (neopterin and lipopolysaccharide-binding protein) will provide valuable information for monitoring the effect of pharmacotherapy of acute brucellosis. Indicators of lipopolysaccharide-binding protein and neopterin in the serum of patients with brucellosis should be considered as a marker of inflammatory activity and as a predictor of outcome of acute brucellosis.