Open AccessGENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
Author(s) -
Васильева Нелия Рафаэлевна,
А. А. Вязовая,
Viacheslav Zhuravlev,
Н. С. Соловьева,
Igor Mokrousov,
О. В. Нарвская
Publication year - 2016
Publication title -
infekciâ i immunitet
Language(s) - English
Resource type - Journals
eISSN - 2313-7398
pISSN - 2220-7619
DOI - 10.15789/2220-7619-2016-2-179-183
Subject(s) - tuberculosis , mycobacterium tuberculosis , medicine , epidemiology , genotype , drug resistance , disease , population , biology , pathology , microbiology and biotechnology , environmental health , genetics , gene
Here, we present clinical and epidemiological analysis of 85 Russian cases of pulmonary tuberculosis caused by an extensively drug-resistant M. tuberculosis strains. As defined by spoligotyping, M. tuberculosis strains belonged to the following genetic families: Beijing — 81.2%, which significantly exceeds the prevalence rate of this genotype (50%) in M. tuberculosis population across Russia; LAM — 14.1% and Ural — 4.7%. Among patients infected with Beijing strains prevailed alcohol and tobacco abused males; the main source of infection were family and penitentiary contacts. This group of patients has been characterized by a variety of clinical forms of lung disease with the prevalence of fibro-cavernous tuberculosis and a significant proportion of patients with interrupted treatment. Regardless of the M. tuberculosis strain genotype, the extensively drug-resistant pulmonary tuberculosis is characterized by severe course leading to the chronic disease with the relapses and poor response to anti-tuberculosis treatment, requiring repeated hospitalizations and surgical treatments.