Open AccessETIOLOGICAL STRUCTURE OF VIRAL RESPIRATORY DISEASES IN ADULT PATIENTS WITH BRONCHIAL ASTHMA EXACERBATION AND CHRONICAL BRONCHIOLITIS OBLITERANS
Author(s) -
В. З. Кривицкая,
Anna Sominina,
М. А. Петрова,
И. В. Амосова,
В. Г. Майорова,
Maria Pisareva,
Ж. В. Бузицкая,
М П Грудинин,
А. К. Голованова,
Ekaterina Petrova,
Ludmila Fiodorovna Kovaleva,
Kiseleva Ev
Publication year - 2015
Publication title -
infekciâ i immunitet
Language(s) - English
Resource type - Journals
eISSN - 2313-7398
pISSN - 2220-7619
DOI - 10.15789/2220-7619-2015-1-45-54
Subject(s) - bronchiolitis , medicine , exacerbation , asthma , respiratory system , virus , respiratory tract , immunology , bronchiolitis obliterans , lung , lung transplantation
Exacerbation of bronchial asthma (BA) and common deterioration of health during chronic bronchiolitis obliterans (ChBO) are associated with viral infections in adults in 64 and 83% respectively. Mixed virus-viral associations were shown in 21–25% of cases. Respiratory syncytial infections were diagnosed with the highest frequency (50%) in patients with BA. Influenza A(H1N1)pdm09 and adenoviral infections dominated in persons with ChBO in 50 and 42% of cases, respectively. Response of virus-specific IgG in patients with BA and ChBO indicates the acute course of influenza A(H1N1)pdm09 (63% of seroconversions). There were no reactions of IgG which is specific to respiratory syncytial virus in 75% of cases and to adenovirus in 83% of cases, that is the risk factor for occurrence of latent/persistent infection. Presence of structural components of respiratory syncytial virus in the upper respiratory tract had been revealed in three patients with asthma within at least 21–28 days. Respiratory syncytial viral infections and pandemic influenza A(H1N1) pdm09 in patients with BA and ChBO are characterized by the presence of an allergic component, which is indicated by the high levels of virus-specific IgE in blood. An adenoviral infection, in contrast, has no such peculiarity.