Open AccessTHE CHARACTERIZATION OF PROAPOPTOTIC ACTIVITY OF LIPOPOLYSACCHARIDE IN ISOLATED SUBPOPULATIONS OF HUMAN T-LYMPHOCYTES
Author(s) -
Е. Н. Филатова,
Е. В. Анисенкова,
Н. Б. Преснякова,
N.V. Neumoina,
Т. Д. Сычева,
О. В. Уткин
Publication year - 2015
Publication title -
infekciâ i immunitet
Language(s) - English
Resource type - Journals
eISSN - 2313-7398
pISSN - 2220-7619
DOI - 10.15789/2220-7619-2014-4-347-352
Subject(s) - cytotoxic t cell , lipopolysaccharide , apoptosis , immune system , activator (genetics) , effector , cd8 , immunology , biology , microbiology and biotechnology , chemistry , biochemistry , in vitro , receptor
Lipopolysaccharide (LPS) is used as activator and inductor of immune cells apoptosis in case of infectious processes modeling. It is not clear if LPS is direct inductor of apoptosis in human T-cells. The subpopulations of effector and naive CD4+ T-helper and CD8+ cytotoxic T lymphocytes of human peripheric blood were isolated and cultivated in presence of LPS. It has been shown that LPS was inductor of apoptosis in studying T-cells populations.