Open AccessMECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS
Author(s) -
А. В. Ершов
Publication year - 2014
Publication title -
infekciâ i immunitet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 5
eISSN - 2313-7398
pISSN - 2220-7619
DOI - 10.15789/2220-7619-2014-2-167-172
Subject(s) - mitosis , biology , microbiology and biotechnology , epithelium , koilocyte , pathology , cervical cancer , cervical intraepithelial neoplasia , cancer , genetics , medicine
. The 1044 biopsies from HPV-positive cervical epithelia were tested by cytological, histological, immunomorphological methods and PCR. One of the mechanisms of genesis of cervical cancer is damage of mitotic apparatus owing to association E7 HPV with NuMA 1, leads to infringement of distribution of chromosomes and virus DNA between daughter cells, shown pathological mitosis and integration of virus DNA. Infringements of differentiation of cells at CIN testified to their delay in pre-mitotic phases of cellular cycle unlike SCC which cells, having finished mitosis, are capable to the differentiation, accompanied by infringement of intercellular adhesion and neoanginesis. Genesis koilocytes and the cells of leukoplakia it is caused by defeat HPV basal cells.