Open AccessSignificance of individual management plan for the patients with hereditary lymphangioedema during pregnancy and lactation, and in newborns
Author(s) -
Ele. Bobrikova,
А. Р. Денисова,
Т. С. Котомина,
Sofia A. Serdotetskova,
Daria Fomina
Publication year - 2020
Publication title -
medicinskaâ immunologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.133
H-Index - 6
eISSN - 2313-741X
pISSN - 1563-0625
DOI - 10.15789/1563-0625-soi-1930
Subject(s) - hereditary angioedema , disease , medicine , pregnancy , multidisciplinary approach , intensive care medicine , multidisciplinary team , pediatrics , pathology , immunology , social science , genetics , sociology , biology , nursing
Hereditary angioedema (HAE) is a genetically caused orphan disease with a high risk of developing life-threatening attacks, thus requiring availability for up-to-date information on this problem for the doctors of any specialties. A limited number of observations determine the value of the analysis for each clinical case. Many facets of clinical manifestations, a list of predisposing and triggering factors, as well as limitations of some diagnostic and therapeutic algorithms, require the development of individual management schemes under distinct clinical situations. In this paper, we present the unique clinical cases with certain limitations, describing unexpected onset of the disease in the course of pregnancy, management aspects during delivery and post-delivery periods in a women with a previously confirmed HAE diagnosis. Adapted diagnostic algorithms of postnatal diagnostic verification are presented for children with burdened genetic history. We express some assumptions about involvement of a multidisciplinary team of specialists, personalized approach to building a management plan with an “online” correction depending on observation stage of НАЕ patient.