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Efficacy of Bath‐Administered Flumequine and Oxolinic Acid in the Treatment of Vibriosis in Small Atlantic Halibut
Author(s) -
Samuelsen Ole B.
Publication year - 1997
Publication title -
journal of aquatic animal health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 52
eISSN - 1548-8667
pISSN - 0899-7659
DOI - 10.1577/1548-8667(1997)009<0127:eobafa>2.3.co;2
Subject(s) - oxolinic acid , flumequine , halibut , hippoglossus hippoglossus , vibrio anguillarum , biology , microbiology and biotechnology , antibiotics , fishery , fish <actinopterygii> , bacteria , vibrio , ciprofloxacin , nalidixic acid , genetics , enrofloxacin
In this investigation, the efficacies of bath‐administered flumequine and oxolinic acid in the treatment of vibriosis in small Atlantic halibut Hippoglossus hippoglossus were examined. In a laboratory challenge experiment, halibut (3–5 g) were exposed to Vibrio anguillarum strain (isolate HI 11347) at a concentration of 4.0 × 10 8 bacteria/mL for 30 min. Bath treatments, initiated 24 h after challenge at a concentration of 150 mg of flumequine or 200 mg of oxolinic acid per liter for 72 h, significantly ( P < 0.05) lowered the V. anguillarum ‐specific mortality in the drug‐treated groups compared with the untreated control group. In another trial in which the bacterial challenge was reduced to 3.2 × 10 8 bacteria/mL (80% of initial dose) and the bath treatment with flumequine (150 mg/mL) was begun on days 2, 3, or 5 postchallenge, the cumulative mortality was significantly ( P < 0.05) different from the control group only when treatment was initiated on day 2 postchallenge. Bacterial examination of kidneys from dead and surviving fish indicated the pathogen was quickly and effectively eliminated by the antibacterials.