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Optimal Dosage of Erythromycin Thiocyanate in a New Feed Additive to Control Bacterial Kidney Disease
Author(s) -
Peters K. Kenneth,
Moffitt Christine M.
Publication year - 1996
Publication title -
journal of aquatic animal health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 52
eISSN - 1548-8667
pISSN - 0899-7659
DOI - 10.1577/1548-8667(1996)008<0229:odoeti>2.3.co;2
Subject(s) - dose , biology , erythromycin , oncorhynchus , zoology , fish <actinopterygii> , chinook wind , aquaculture , antibiotics , fishery , pharmacology , microbiology and biotechnology
An experimental feed additive containing erythromycin thiocyanate was formulated into fish feeds and tested to determine the optimal dosage and length of administration to treat acute infections of Renibacterium salmoninarum in chinook salmon Oncorhynchus tshawytscha . Trials were conducted on groups of yearling salmon acclimated and held in the laboratory at 10°C or 14°C in both the winter and spring. Parametric and nonparametric statistical analyses were used to assess survival rates during the tests and to evaluate the condition of fish alive at the completion of the trials. Survival was highest in trials of fish held at 10°C and among those fish that consumed higher quantities of erythromycin for 28 d of continuous therapy. Because portions of the daily rations were more likely to be refused when target dosages exceeded 100 mg/kg body weight, particularly in winter conditions, we recommend a standard therapeutic dosage of 100 mg/kg for 28 d.