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Field Efficacy Trials of the Antibacterial Sarafloxacin‐Hydrochloride (A‐56620) for Treatment of Edwardsiella ictaluri Infections in Channel Catfish
Author(s) -
Johnson Michael R.,
Smith Katherine L.,
Boyle Carolyn R.
Publication year - 1992
Publication title -
journal of aquatic animal health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 52
eISSN - 1548-8667
pISSN - 0899-7659
DOI - 10.1577/1548-8667(1992)004<0244:fetota>2.3.co;2
Subject(s) - edwardsiella ictaluri , catfish , ictalurus , biology , veterinary medicine , zoology , fish <actinopterygii> , medicine , fishery
Three field trials were conducted to determine the efficacy of Sarafin® (sarafloxacinHCl) in the treatment of naturally induced infections of Edwardsiella ictaluri in channel catfish Ictalurus punctatus . Administering Sarafin in the feed for 5 d at a dose of 10 or 12.5 mg/kg of fish proved efficacious in treating channel catfish infected with E. ictaluri in all three field trials. Average survival of the nonmedicated group was 43% in trial 1, 11°% in trial 2, and 59% in trial 3. Survival of the corresponding Sarafin‐medicated groups averaged 68, 48, and 73%. Antibiotic therapy with Sarafin significantly (P < 0.05) improved survival in all trials. In two trials, fish fed Sarafinmedicated feed gained more weight (P < 0.05) than did fish fed nonmedicated feed. In one trial, feed medicated with Romet® (sulfadimethoxine‐ormetoprim) was also tested. Romet was administered in the feed at 100 mg/kg of fish, which is twice the recommended dose. This dose was chosen to match the feeding rate of Sarafin (fed at 2% body weight). Romet increased the average percent survival to 82%, which was significantly (P < 0.05) higher than that for fingerlings fed either the nonmedicated feed (59%) or the Sarafin‐medicated feed (73%). Fish medicated with Romet feed also gained significantly (P < 0.05) more weight than did fish fed nonmedicated feed.