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Survival of Juvenile Chinook Salmon Challenged with Renibacterium salmoninarum and Administered Oral Doses of Erythromycin Thiocyanate for Different Durations
Author(s) -
Moffitt Christine M.
Publication year - 1992
Publication title -
journal of aquatic animal health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 52
eISSN - 1548-8667
pISSN - 0899-7659
DOI - 10.1577/1548-8667(1992)004<0119:sojcsc>2.3.co;2
Subject(s) - erythromycin , biology , dose , oncorhynchus , juvenile , antibiotics , zoology , fish <actinopterygii> , veterinary medicine , physiology , microbiology and biotechnology , pharmacology , medicine , fishery , ecology
Erythromycin thiocyanate was administered orally at three daily dosages (50, 100, and 200 mg/kg body weight) for 7, 14, or 21 d to duplicate groups of yearling chinook salmon Oncorhynchus tshawytscha challenged with an intraperitoneal inoculation of kidney disease bacterium, Renibacterium salmoninarum . Two experiments were conducted sequentially to test the effects of the drug and bacterium challenge at 12 and 8°C. In each experiment, the number offish surviving at the end of the trial was significantly higher in tanks offish administered erythromycin, and survival was highest in tanks of fish administered the highest dosage of erythromycin for 21 d. In tests conducted at 12°C, mortality from bacterial kidney disease began much sooner than in tests conducted at 8°C. How long the drug was administered was a significant factor in tests conducted at both temperatures; survival increased in drug treatments of longer duration. Palatability of feed may be a complicating factor in determining the most appropriate drug treatment, because fish refused some of the rations containing the highest concentrations of erythromycin.