Premium
Acute and Subchronic Toxicity of Cyclopiazonic Acid to Channel Catfish
Author(s) -
Jantrarotai Wimol,
Lovell Richard T.
Publication year - 1990
Publication title -
journal of aquatic animal health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 52
eISSN - 1548-8667
pISSN - 0899-7659
DOI - 10.1577/1548-8667(1990)002<0255:aastoc>2.3.co;2
Subject(s) - cyclopiazonic acid , catfish , ictalurus , biology , necrosis , toxicity , hemoglobin , acute toxicity , hematocrit , medicine , endocrinology , biochemistry , fish <actinopterygii> , fishery , genetics , intracellular
The 96‐h median lethal dose (LD50; dose that is lethal to 50% of test organisms) of cyclopiazonic acid (CPA) injected intraperitoneally (IP) into channel catfish Ictalurus punctatus (average weight, 19 g) was 2.82 mg/kg of body weight, with a 95% confidence interval of 2.483.12 mg/kg. The acute effects of CPA were characteristic of a neurotoxin. Some fish injected with CPA doses of 2.40 mg/kg of body weight or higher showed severe convulsions, tetany, and death within 30 min postinjection. There were no lesions in the organs of the moribund fish examined grossly and histologically. Cyclopiazonic acid fed for 10 weeks at a concentration of 100 μg/kg of diet had a growth‐suppressing effect (P < 0.05) on channel catfish (average weight, 7.5 g), and a concentration of 10,000 μg/kg caused accumulation of proteinaceous granules in renal tubular epithelium and necrosis of gastric glands. Cyclopiazonic acid had no effects on hematocrit, hemoglobin concentration, and erythrocyte and leukocyte counts (P > 0.05).