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Dose Titration of Sarafloxacin (A‐56620) against Edwardsiella ictaluri Infection in Channel Catfish
Author(s) -
Plumb J. A.,
Vinitnantharat S.
Publication year - 1990
Publication title -
journal of aquatic animal health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 52
eISSN - 1548-8667
pISSN - 0899-7659
DOI - 10.1577/1548-8667(1990)002<0194:dtosaa>2.3.co;2
Subject(s) - edwardsiella ictaluri , catfish , ictalurus , biology , veterinary medicine , fish <actinopterygii> , body weight , zoology , fishery , medicine , endocrinology
Two dose‐titration studies were performed with sarafloxacin (A‐56620) on channel catfish Ictalurus punctatus infected with Edwardsiella ictaluri . Fish were infected with E. ictaluri by water‐bath exposure and subsequently fed rations for 5 d to equal 0, 2, 6, 10, or 14 mg sarafloxacin/kg body weight per day. In trial I, mortality was significantly reduced from 69% for fish receiving no medication to 17% for those receiving 10 or 14 mg sarafloxacin/kg per day (P ≤ 0.01). In trial II, mortality was reduced from 33% of the nonmedicated infected group to 5 and 10% offish receiving 10 and 14 mg sarafloxacin/kg per day, respectively. Fish receiving 2 or 6 mg sarafloxacin/kg per day had intermediate mortality rates.