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Cellular Inflammatory Response of Rainbow Trout to the Protozoan Parasite that Causes Proliferative Kidney Disease
Author(s) -
Macconnell Elizabeth,
Smith Charlie E.,
Hedrick Ronald P.,
Speer C. A.
Publication year - 1989
Publication title -
journal of aquatic animal health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 52
eISSN - 1548-8667
pISSN - 0899-7659
DOI - 10.1577/1548-8667(1989)001<0108:cirort>2.3.co;2
Subject(s) - rainbow trout , biology , parasite hosting , salmo , kidney , macrophage , hyperplasia , immune system , immunology , pathology , microbiology and biotechnology , fish <actinopterygii> , endocrinology , medicine , fishery , biochemistry , world wide web , computer science , in vitro
The cellular inflammatory response of rainbow trout Oncorhynchus mykiss (formerly Salmo gairdneri ) to the myxozoan parasite PKX that causes proliferative kidney disease was investigated. The response was studied from 3 to 20 weeks after the fish were injected with infected kidney homogenate. Kidney samples were examined by light and electron microscopy. In contrast to most myxosporeans, PKX provoked a severe host response. Parasites were found in peritubular capillaries and sinusoids 3 weeks postinjection. The initial response to PKX was hemopoietic hyperplasia followed by a marked granulomatous nephritis that was resolved by termination of the study at 20 weeks postinjection. The macrophage was the predominant cell type involved in the inflammatory response to PKX. We presume that the macrophage effectively interrupts the development of PKX and eliminates the parasite from the host.