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Oral Toxicity of Rotenone for Common Carp
Author(s) -
Fajt James R.,
Grizzle John M.
Publication year - 1993
Publication title -
transactions of the american fisheries society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 86
eISSN - 1548-8659
pISSN - 0002-8487
DOI - 10.1577/1548-8659(1993)122<0302:otorfc>2.3.co;2
Subject(s) - rotenone , cyprinus , toxicity , toxicology , carp , median lethal dose , lethal dose , chemistry , common carp , zoology , biology , pharmacology , fish <actinopterygii> , fishery , biochemistry , organic chemistry , mitochondrion
Rotenone was administered in a food bolus by gavage to common carp Cyprinus carpio . The experimental formulations also contained a constant level of a surfactant, polysorbate 80. The lethal dose of rotenone to 50% of the test animals (LD50) was 8.1 mg/kg of fish with a 95% confidence interval of 7.7–8.5 mg/kg. The extrapolated lethal dose to 99% of the test animals was 11.6 mg/kg. Behavior of the fish receiving an oral dose of rotenone was similar to that of fish exposed to rotenone in water, and all deaths occurred within 16 h of gavage. Rotenone was made available for absorption via the intestine by including a surfactant in the formulation.