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Effect of Methotrexate, Kenalog, and Cyclophosphamide on the Antibody Response of Steelheads to Aeromonas salmonicida
Author(s) -
Chen Martin F.,
Rohovec J. S.,
Fryer J. L.
Publication year - 1983
Publication title -
transactions of the american fisheries society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 86
eISSN - 1548-8659
pISSN - 0002-8487
DOI - 10.1577/1548-8659(1983)112<561:eomkac>2.0.co;2
Subject(s) - aeromonas salmonicida , cyclophosphamide , methotrexate , immunosuppression , titer , antibody titer , antibody , antibody response , salmo , biology , microbiology and biotechnology , medicine , fish <actinopterygii> , immunology , chemotherapy , fishery
Methotrexate, kenalog, and cyclophosphamide were tested for immunosuppressive activity in steelheads Salmo gairdneri. Three 60‐mg/kg injections of methotrexate prevented an increase in serum antibody titer in fish previously immunized with killed whole cells of Aeromonas salmonicida. No immunosuppression in previously immunized steelheads was observed following injections of kenalog and cyclophosphamide. Received December 3, 1982 Accepted April 20, 1983