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The Uptake, Metabolism, and Elimination of Chlorinated Residues by Goldfish (Carassius auratus) Fed A 14 C‐DDT Contaminated Diet
Author(s) -
Grzenda Alfred R.,
Parts Doris Fort,
Taylor William J.
Publication year - 1970
Publication title -
transactions of the american fisheries society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 86
eISSN - 1548-8659
pISSN - 0002-8487
DOI - 10.1577/1548-8659(1970)99<385:tumaeo>2.0.co;2
Subject(s) - residue (chemistry) , carassius auratus , adipose tissue , zoology , chemistry , metabolism , endocrinology , medicine , biology , biochemistry , fish <actinopterygii> , fishery
Goldfish (Carassius auratus) were exposed to a diet containing 50 nanomoles/gram (nmoles/g) 14 C‐DDT for a maximum of 192 days (total exposure 842 nmoles). Six sacrifices were made during the exposure period and the total residue distribution among the principal tissues determined. The lowest total residue concentrations were noted in muscle, skin, and immature ovary, and the highest in mesenteric adipose, lateral‐line nerve, and testes. There was no correlation between the total lipid content of the tissues and the residue concentrations. Semi‐logarithmic plots of the DDT uptake data, for most tissues, were characterized by an initial period of rapid uptake followed by linear slopes which approached horizontal. In nearly all cases, the regression coefficients were not statistically significant for the reduced phase of uptake. The percentage composition of DDT, DDE, and DDD was determined for the tissues. The percentage of metabolites increased with continued exposure, in spite of the constant and uniform input of DDT. Another group of goldfish was exposed to 561 nmoles 14 C‐DDT in their diet and then placed on a residue‐free ration to determine the rate of residue elimination. The loss rate was exponential, and the residue half‐life values for the tissues averaged 29 days and ranged from 22 to 34 days for lateral‐line nerve and mesenteric adipose, respectively. The differences in half‐life values were not statistically significant.