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Sulfonamide Toxicity in Brook Trout
Author(s) -
Wood E. M.,
Yasutake W. T.,
Snieszko S. F.
Publication year - 1955
Publication title -
transactions of the american fisheries society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 86
eISSN - 1548-8659
pISSN - 0002-8487
DOI - 10.1577/1548-8659(1954)84[155:stibt]2.0.co;2
Subject(s) - sulfamerazine , trout , biology , sulfonamide , toxicity , sterility , reproduction , toxicology , physiology , zoology , medicine , ecology , fishery , fish <actinopterygii> , microbiology and biotechnology , chemistry , antibiotics , sulfadiazine , genetics , stereochemistry
Sterility was observed in female brook trout that were treated with sulfamerazine at frequent intervals for 2 years to control endemic furunculosis. Feeding sulfamerazine for a period of 8 months caused massive kidney damage similar to that observed in humans who develop allergies to “sulfa” drugs. Kidney damage of the type observed would probably cause renal insufficiency which would handicap any physiological function including reproduction. Feeding sulfonamides for periods up to 13 weeks did not produce kidney damage.