Open AccessBlockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis
Author(s) -
Nucharee Yokdang,
Senny Nordmeier,
Katie Speirs,
Heather R. Burkin,
Martin Buxton
Publication year - 2015
Publication title -
integrative cancer science and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2056-4546
DOI - 10.15761/icst.1000139
Subject(s) - metastasis , cancer research , angiogenesis , breast cancer , primary tumor , extracellular , metastatic breast cancer , medicine , in vivo , ca 15 3 , nucleoside diphosphate kinase , mammary tumor , cancer , biology , kinase , ca15 3 , microbiology and biotechnology
Nucleoside Diphosphate Kinase (NDPK), described as NM23 a metastasis suppressor, is found in the culture medium of cancer cells lines suggesting that the kinase may have an extracellular role. We propose that extracellular NM23 released from breast cancers in vivo stimulates tumor cell migration, proliferation and endothelial cell angiogenesis in support of metastasis development.