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Pulsed hormone replacement therapy
Author(s) -
Mukhopadhyay Sambit,
Morris Edward P
Publication year - 2003
Publication title -
the obstetrician and gynaecologist
Language(s) - English
Resource type - Journals
eISSN - 1744-4667
pISSN - 1467-2561
DOI - 10.1576/toag.5.2.91
Subject(s) - hormone replacement therapy (female to male) , climacteric , medicine , hormone replacement , hormone , endocrinology , hypoestrogenism , bone remodeling , menopause , physiology , testosterone (patch)
Physiological decline and subsequent cessation of ovarian function leads to oestrogen deficiency during the perimenopause and postmenopausal years. The beneficial effects of hormone replacement are well known. Hormone replacement is intended to be used for a prolonged period of time to correct the long‐term problems associated with oestrogen deficiency. Despite various routes of administration of oestrogen, nonadherence to treatment remains a problem. Pulsed oestrogen therapy administered nasally has been shown to improve climacteric symptoms and bone density and to affect metabolic markers of lipid and bone metabolism in the same way as conventional hormone replacement.