Diagnosis and management of non‐anti‐D red cell antibodies in pregnancy

•  Anti‐D prophylaxis has reduced the incidence of haemolytic disease of the newborn. •  A variety of non‐anti‐D red cell antibodies can cause a degree of neonatal haemolysis. •  The frequency of antibody testing should be individualised. •  Management of non‐anti‐D alloimmunisation should be aimed at minimising perinatal morbidity.Learning objectives:•  To understand the causes and risk factors for maternal non‐anti‐D antibodies. •  To learn when to initiate invasive testing in the antenatal period. •  To know when to deliver the baby to maximise perinatal outcome. •  To learn about which antibodies can cause fetal hydrops and intrauterine haemolysis.Ethical issues:•  When is it necessary to perform paternal blood tests to determine red cell antibody status? •  When should the mother be delivered in cases where the red cell antibody detected has a weak association with neonatal haemolysis?Please cite this article as: Gajjar K, Spencer C. Diagnosis and management of non‐anti‐D red cell antibodies in pregnancy. The Obstetrician & Gynaecologist 2009;11:89–95.