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Preimplantation testing for chromosome aneuploidy
Author(s) -
Ogilvie Caroline Mackie
Publication year - 2008
Publication title -
the obstetrician and gynaecologist
Language(s) - English
Resource type - Journals
eISSN - 1744-4667
pISSN - 1467-2561
DOI - 10.1576/toag.10.2.088.27396
Subject(s) - aneuploidy , in vitro fertilisation , genetic testing , embryo , chromosome , biology , obstetrics , gynecology , pregnancy , andrology , medicine , genetics , gene
• Around 50% of cleavage stage human embryos obtained by in vitro fertilisation (IVF) have an abnormal number of chromosomes. • Aneuploidy testing has been introduced at some IVF centres with the aim of identifying and removing abnormal embryos and increasing pregnancy success rates. • Randomised controlled trials have indicated that pregnancy and live birth rates are lower for women undergoing aneuploidy testing.Learning objectives:• To understand the nature and frequency of chromosome abnormalities in cleavage stage human embryos. • To understand the rationale underlying aneuploidy testing. • To understand the results of research on aneuploidy testing.Ethical issues:• Should aneuploidy testing be offered, when randomised trials indicate either that it has no effect or that it results in fewer ongoing pregnancies and live births?Please cite this article as: Ogilvie CM. Preimplantation testing for chromosome aneuploidy. The Obstetrician & Gynaecologist 2008;10:88–92.