Open AccessMICRORNA: ROLE IN GH-SECRETING PITUITARY ADENOMA PATHOGENESIS
Author(s) -
Alexander Lutsenko,
Луценко Александр Сергеевич,
Zhanna Belaya,
Белая Жанна Евгеньевна,
Elena Przhiyalkovskaya,
Пржиялковская Елена Георгиевна,
G. A. Melnichenko,
Мельниченко Галина Афанасьевна
Publication year - 2017
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn856
Subject(s) - microrna , pituitary adenoma , biomarker , pituitary tumors , pathogenesis , pathological , adenoma , somatotropic cell , biology , pituitary neoplasm , bioinformatics , pathology , cancer research , medicine , pituitary gland , gene , hormone , genetics
MicroRNA presents small (19–25 nucleotides long) non-coding RNA molecules which regulate gene expression on post-transcriptional level. Numerous studies revealed microRNA’s important role in physiological processes. Moreover, its aberrant expression has been described in many pathological conditions including pituitary tumors. Pituitary adenomas are benign intracranial tumors with various clinical presentations depending on the type of hormone secretion. Prediction of the pituitary adenoma aggressive level and treatment response is challenging due to the lack of reliable clinical predictors or non-invasive biomarkers. MicroRNAs in body fluids could potentially be a minimally invasive biomarker for tumor diagnosis and a predictor of treatment response and prognosis. Some studies reveal that microRNA is specific for a different pituitary adenoma subtypes. In the article, we review existing evidence on microRNA expression in GH-secreting tumors and its possible involvement in pathogenesis of somatotroph tumors.