Open AccessPostconditioning the Heart: Analysis of Experimental and Clinical Data
Author(s) -
L. N. Maslov,
Маслов Леонид Николаевич,
S. Yu. Tsibulnikov,
Цибульников Сергей Юрьевич,
A. V. Mukhomedzyanov,
Мухомедзянов Александр Валерьевич,
A. S. Semenotsov,
Семеноцов Андрей Сергеевич,
А. В. Цепокина,
Цепокина Анна Викторовна,
M. V. Khutornaya,
Хуторная Мария Владимировна,
Anton G. Kutikhin,
Кутихин Антон Геннадьевич,
Irim,
Нам Ирина Феликсовна
Publication year - 2016
Publication title -
vestnik rossijskoj akademii medicinskih nauk
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 15
eISSN - 2414-3545
pISSN - 0869-6047
DOI - 10.15690/vramn628
Subject(s) - inotrope , medicine , cardiology , myocardial infarction , tetralogy of fallot , limiting , heart disease , mechanical engineering , engineering
Experimental atherosclerosis and hypercholesterolemia may reduce or eliminate the infarct-limiting and anti-apoptotic effect of postconditioning (PC). Experiments in rats and mice indicate that the PC may be quite effective in patients with diabetes type 2 or metabolic syndrome. Experimental data suggest that hypertension or the past myocardial infarction is not an obstacle for the implementation of cardioprotective effect of PC. It was established that that aging does not preclude the implementation of PC cardioprotective effect. Inotropic effect of IP can simulate on isolated human atrial trabeculae. The clinical observations suggest that the PC in patients with tetralogy of Fallot and patients with operations on the valves improves the outcome of cardiac surgery. It was established that PC in these patients reduces the intensity of reperfusion necrosis of cardiomyocytes, improves the pumping function of the heart, reduces the inotropic support, shorten the extubation time.